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At higher doses, reductions exceeded 40%

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Backed by the robust ESSENCE trial, Wegovy showed remarkable rates of steatohepatitis resolution and fibrosis improvement a breakthrough for patients with moderate-to-advanced liver scarring

Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide