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10.1146/annurev-pathol-011110-130203 65 FengY.SuL.ZhongX.GuohongW.XiaoH.LiY.et al (2016)

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Targeted delivery remains one of the central challenges to the broader applications of oligonucleotide-based therapies, and achieving efficient tissue-selective delivery beyond the liver remains a critical unmet need

They do not treat the autoimmune process No clinical evidence demonstrates that GLP-1 receptor agonists reduce thyroid antibody levels or modify the autoimmune destruction of thyroid tissue