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If you spend 10 weeks microdosing before reaching 2.5 to 5 mg, your results over 72 total weeks may be modestly lower due to the delayed therapeutic onset, but adherence benefits may compensate

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As outcome trials such as SURPASS-CVOT, TREASURE-CKD, and SYNERGY-NASH conclude, they will clarify tirzepatides long-term role in cardiovascular and renal protection

SURMOUNT-3 tested a different question: can tirzepatide maintain and extend weight loss achieved through an initial intensive lifestyle intervention
