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2021 Mar 3;19(1):40
10.1161/CIRCULATIONAHA.109.924977 [EL 2
Do not use the pen if the liquid is cloudy, discoloured, or contains particles

3 This precipitated a series of events culminating in the Food and Drug administration (FDA) requirement for cardiovascular safety studies for all new hypoglycemic agents

The letter of medical necessity is the single most important document
