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Studies using magnetic resonance imaging (MRI) and proton density fat fraction (MRI-PDFF) measurements have shown significant reductions in hepatic steatosis with semaglutide and liraglutide treatment

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This is why subcutaneous delivery is at the moment the only feasible route for all GLP-1 receptor agonists

This also activates pro-inflammatory mediators in adipose tissue which together ultimately activate hepatic stellate cells.[94], [95], [96]CVC was evaluated in a phase IIb, randomised, placebo-controlled, multinational study of 289 patients with biopsy proven NASH (NAS 4, with fibrosis stage 1-3) and diabetes or metabolic syndrome (CENTAUR)