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Given the limitations of the in vitro model using one human adipocyte cell line, further studies are necessary to confirm the hypothesis that nutrients, by stimulating the secretion of GLP-1, may influence the expression of irisin and thus modulate the mitochondrial metabolism of adipocytes.

Furthermore, in the majority of cases, eligibility for nonsurgical treatment does not differ greatly in this group compared with non-GLP-1 patients

More information can be found under 'Post-authorisation safety studies'

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Exertional syncope is an alarm symptom that demands a comprehensive evaluation with 4 diagnostic tests: ECG, echocardiography, exercise treadmill test, and Holter monitor