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[DOI] [PMC free article] [PubMed] 83.Manini AF, Kabrhel C, Thomsen TW

Mechanism of Action Binds to sulfonylurea receptor (SUR1) on pancreatic -cells Closes ATP-sensitive K channels depolarization of -cell membrane Opens voltage-gated Ca channels influx of Ca Triggers insulin secretion blood glucose Works only in patients with functional -cells Pharmacokinetics Absorption: Well absorbed orally Distribution: Widely distributed

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The GLP-1 pathway suppresses appetite and improves how your body handles glucose

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