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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Liu J, et al

The hallmark symptoms include persistent diarrhea (often with blood or mucus), abdominal cramping, urgency, and rectal pain

Adolescents with a BMI of 95th percentile or higher may also be eligible for the treatment starting at age 12

Possible effects on energy balance and body composition: Some data suggest modest improvements in energy expenditure and preferential loss of fat mass versus lean mass, but appetite suppression is the dominant driver of weight loss
