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Most major blood donation organizations in the US, including the American Red Cross, do not automatically disqualify donors taking these medications for weight loss or diabetes management

When clinically appropriate, treatment plans may include evaluation of FDA-approved GLP-1 or GIP-based medications under the supervision of a licensed healthcare provider

1 Research Highlights GLP-1 RA users had 21% higher hypersomnolence at 1 year

The activation of microglia and astrocytes lead to the accumulation of cytokines, NF-B pathway activation, and oxidative damage to proteins

However, there are limitations inherent with this method as a surrogate to evaluating loss of muscle mass (few studies specifically measure muscle mass)