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As an ObGyn dedicated to helping patients achieve their weight loss goals, I often hear concerns about the side effects of GLP-1 ...

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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

Unlike traditional GLP1 receptor agonists, tirzepatide is more selective for the GIP receptor, resulting in a more balanced activation of these receptors

A collaborative study carried out by the team "Functional Pharmacology and Physiopathology of Membrane Receptors" led by Dr Ralf Jockers, and published in Nature Metab., shows that mutations of the gene encoding the receptor of glucagon-like peptide 1 (GLP1R) affect metabolic traits such as glucose and body weight management and modulates the effectiveness of GLP1R agonists clinically used to treat diabetic and/or obese patients.