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Weight loss accounts for part of the migraine reduction, but GLP-1 receptor activation also directly reduces neuroinflammation and stabilizes blood vessel reactivity

Additionally, hormonal changes occur: levels of leptin (which signals fullness) drop, while ghrelin (which triggers hunger) can increase

Current international guidelines emphasize individualized glycemic targets while minimizing hypoglycemia risk and weight gain when selecting antidiabetic therapies [1]

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