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Additionally, subgroup analyses were conducted to evaluate potential effect modification by sex, age, BMI, smoking status, and antihypertensive medication use, with P-values for interaction calculated to determine statistical significance

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Together, these effects help improve blood sugar control and reduce calorie intake, which can lead to weight loss over time

For example, in both diabetics and non-diabetics, Metformin was associated with fewer cases of several age-related diseases as well as lowering all-cause mortality

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