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The company is exploring higher-dose formulations and has signalled plans to investigate the full weight-loss potential of the combination in further studies

SGLT-2 inhibitors increase the risk of genital infections, with a number needed to harm (NNH) of 7 (95% CI, 6 to 9) over five years

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This effect is mediated through modulation of signaling pathways TGF- /Smad and peroxisome proliferator-activated receptor gamma (PPAR), which regulate HSC activation and extracellular matrix (ECM) synthesis (30, 31)

Certain individualssuch as those with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2should not use GLP-1 receptor agonists