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Historically, they have been used mainly to treat type-2 diabetes

Conclusions/interpretation In a population with type 2 diabetes and high risk of CVD, semaglutide and empagliflozin significantly reduced cortical ADC compared with placebo, indicating microstructural changes in the kidneys

Further studies in models more closely reflecting type 2 diabetes are warranted to clarify the underlying mechanisms and translational relevance

GLP-RT's tri-agonist receptor activity also makes it relevant for research examining metabolic rate and energy expenditure pathways