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"We need more data on the long-term effects and other outcomes related to cardiovascular health, particularly in lower-risk individuals," says Eva Madrid, co-lead researcher from the Universidad de Valparaso, Chile

In addition to weight loss, both Novo Nordisk and Eli Lilly have been trying to expand the indications for GLP-1 more medical conditions, including sleep apnea, non-alcoholic steatohepatitis (NASH), metabolic dysfunction-associated steatohepatitis (MASH), cardiopulmonary disease, stroke, kidney disease, hypertension, Parkinsons Disease, and Alzheimers Disease

However, important limitations exist in the current evidence: Most studies have been relatively small with short follow-up periods Many participants had concurrent obesity, making it difficult to separate weight loss effects from direct effects on binge eating behaviour Long-term efficacy and safety data specifically for binge eating disorder are lacking The psychological and behavioural components of BED may require interventions beyond pharmacological appetite suppression There is no official link established by regulatory bodies between GLP-1 agonists and binge eating disorder treatment

In addition to stimulating the GLP-1 receptor, tirzepatide also activates the GIP receptor

This is when thyroid monitoring becomes critical because the enhanced levothyroxine absorption from delayed gastric emptying may push you into slight overmedication