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These agents mimic the incretin hormones, which enhance insulin secretion and suppress glucagon release, leading to potent effects on weight reduction and glycemic control

But for many people searching for alternatives, the real issue is cost or access to the brand-name product, making compounded tirzepatide the closest possible "alternative." Regulatory changes have complicated this landscape significantly

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This is evident from experiments describing the effects of specific PI3K and mTOR inhibitors, which completely abrogated the metabolic actions of Exendin-4 (Fig