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There is no direct head-to-head trial, but the mechanistic difference, particularly the addition of glucagon receptor activity increasing energy expenditure, distinguishes the two compounds

In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)

Remember that the habits youve built while on Mounjaro are just as important as the medication itself