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The data showed that GI side effects nearly doubled when participants jumped straight to higher doses instead of titrating from the lowest starting dose

Looking at the side effect profiles side by side, a few patterns stand out

In the morning your GI tract is sped up which may limit the absorption of thyroid hormone

GLP-1 injections: Evidence and efficacy In contrast to patches, GLP-1 injections have extensive clinical evidence supporting their effectiveness: Clinical trial results Wegovy (semaglutide) : The STEP clinical trials involved thousands of participants and showed average weight loss of 15% after 68 weeks