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How They Work: Key Differences While both semaglutide tirzepatide are used for weight loss and blood sugar control, they work in slightly different ways
These medications support weight loss, but avoiding side effects like muscle loss and severe constipation requires effort

2021;161(3):1030-1042.e8

53 The above findings indicate that GLP-1RAs inhibit food intake and cause weight loss mainly by acting on different brain regions, which also supports the evidence of long-acting GLP-1RAs penetrating incomplete BBB in certain areas

Long chain saturated and unsaturated fatty acids exert opposing effects on viability and function of GLP-1-producing cells: mechanisms of lipotoxicity