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The FLOW trial demonstrated that semaglutide decreased kidney disease progression along with cardiovascular events in T2DM patients who had CKD while reducing HF events by 27% [58]

The primary concern relates not to direct drug interactions between most injectable GLP-1 agonists and levothyroxine, but rather to the potential impact on thyroid monitoring and the theoretical risk associated with thyroid C-cell tumours observed in animal studies

The SURPASS program, which targeted patients with type 2 diabetes [29, 36,37,38,39,40,41,42], and the SURMOUNT program, which included individuals with obesity but without diabetes [43,44,45], both reported clinically significant reductions in body weight

Constipation symptoms have been reported to last longer than those of the other GI AEs