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Dopamine agonists (FDA-approved pramipexole, ropinirole, or rotigotine) are effective but carry risks of augmentation (paradoxical worsening of symptoms) and impulse control disorders with long-term use

Research consistently shows that without addressing the physiological root causes of weight gain, most people regain the weight they lose within two years

But tirzepatide proved that when GIP and GLP-1 receptors are activated together, the combination produces substantially more weight loss than either pathway alone

CD gave substantial contribution to drafting the article or revising it critically for important intellectual content and final approval of the version to be published