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Indeed, both in rodents and humans, GLP-1 infusion increased fractional sodium excretion [20], which has been linked to the finding that sodium is more rapidly excreted following an oral versus equivalent IV sodium load in a number of experimental studies in healthy individuals, independent of factors such as atrial natriuretic peptide (ANP) and aldosterone [22]

Ozempic generally wins for sheer weight loss numbers it delivers 1015% body weight reduction (sometimes more), while Contrave typically lands at 510%

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The most established connection involves mechanical stress reduction on weight-bearing joints

Consider: If blood sugar is well-controlled on Trulicity, switching may not be necessary