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Key advances In the SURMOUNT-1 trial for obesity, adults with overweight or obesity without type 2 diabetes mellitus achieved placebo-subtracted weight loss of up to 20% after 72 weeks of the GLP1GIP receptor co-agonist tirzepatide, with a similar safety profile to high-dose semaglutide 5

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Significant weight changes: Rapid weight loss or gain, as well as eating disorders such as anorexia or bulimia, can affect hormonal balance

Brown noted that, without this new evidence, some women taking GLP-1s might consider terminating otherwise wanted pregnancies out of safety concerns

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