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doi: 10.1016/s0278-2626(02)00519-5
CANVAS demonstrated a 14% reduction in MACE in patients with T2DM and a high cardiovascular risk ( 4.1.2 Cardiovascular results in studies aimed at CVD The CREDENCE clinical trial evaluated the effects of canagliflozin (100 mg daily) versus placebo in 4,401 patients with T2DM and CKD
Clinical trials (SURMOUNT-1) have demonstrated significant weight loss outcomes, with participants losing approximately 15% (5 mg dose), 19.5% (10 mg dose), and 20.9% (15 mg dose) of their body weight over 72 weeks
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A high-quality Probiotic supports a balanced microbiome, reduces bloating, and may improve GLP-1 signaling in the gut itself
