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Positioning in guidelines In the NICE NG28 guideline, 3 the DPP-4 inhibitors may be used first-line when metformin is contraindicated or not tolerated

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2 These cysts are formed in the ovarian follicles due to hormonal imbalance, specifically hyperandrogenism, which is a key manifestation of PCOS, along with ovulatory dysfunction and altered polycystic ovarian morphology