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PC2 in pancreatic alpha-cells cleaves proglucagon to generate glucagon, while PC1/3 in gut enteroendocrine L-cells yields GLP-1 and GLP-2 alongside other fragments (14, 2730)

The disproportionality signal they identified disappeared only when they removed this subgroup of patients from their analysis

Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function

This strategy allowed us to estimate several mitochondrial parameters in response to GLP-1R stimulation

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