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i.v.) the bioavailability of the exendin-4 administered via the intestinal route is 19% for delivery to the portal vein, and 9% in the peripheral bloodstream

evidenced that the liraglutide treatment decreased oxidative stress and it was independent of the impact of liraglutide on glucose metabolism [125]

In 1902 they discovered in anaesthetised dogs that a chemical messenger secreted by the intestinal lining into the bloodstream helped to stimulate the pancreas to produce digestive juices whenever food or acid was introduced into the duodenum

Zhang K, Wiedemann S, Dschietzig M, Cremers MM, Augstein A, Poitz DM, et al

Greco EV, Russo G, Giandalia A, et al