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Formulation and dosing are customized

In addition, denaturation, isolation, and elimination of the GLP-1R N-terminal domain result in loss of affinity for the peptide25)

Hjerpsted JB, Flint A, Brooks A, Axelsen MB, Kvist T, Blundell J

Borup C, Vinter-Jensen L, Jrgensen SPG, et al

Nonetheless, research focusing on their safety during pregnancy is scarce, with existing studies primarily addressing metabolic effects rather than gestational safety.224 Given that GLP-1/GIP dual agonists modulate multiple metabolic pathways, further research is necessary to elucidate their potential impact on fetal development.227 Additionally, safety assessments of GLP-1RAs and GLP-1/GIP dual agonists in non-pregnant women have identified common adverse reactions, including gastrointestinal discomfort and anorexia