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Discussion The process of OA has been attributed to several processes, such as aging and excessive mechanical loading, which trigger a series of molecular events leading to cell death and structural damage in articular cartilage, particularly inflammation 23,24,25

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However, despite their clinical efficacy, GLP-1RAs have been associated with an increased risk of gallbladder disease, including gallstone formation known as cholelithiasis and inflammation of the gallbladder called cholecystitis, especially with prolonged use and higher doses