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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Neuen BL, Ohkuma T, Neal B, Matthews DR, de Zeeuw D, Mahaffey KW, et al

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Semaglutide's extended half-life enables: Sustained glycemic control : Continuous insulin secretion enhancement and glucagon suppression throughout the interdose interval Persistent appetite suppression : Ongoing central nervous system effects reducing caloric intake Convenient dosing : Once-weekly administration improving adherence compared to daily or multiple-daily injections Patients should understand that semaglutide requires several weeks to reach steady-state concentrations after each dose change (approximately 4-5 half-lives), with full clinical effects typically observed after completing the recommended dose titration schedule

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