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GLP-1 RAs and naltrexone/bupropion have shown efficacy in attenuating hedonic drive through hypothalamic and mesolimbic modulation, offering therapeutic tools beyond caloric restriction [200]

Significant visible change in abdominal fat

Diabetes Metab J (2022) 46:40213

Conclusion In this large-scale FAERS analysis using a concurrent full-database comparator, tirzepatide was associated with persistently lower reporting odds for heart failure across all sensitivity strata, including HCP-restricted analyses

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