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The first identified incretin was a gastric inhibitory peptide (GIP) with the activity of inhibiting the secretion of gastric acid, which was isolated from porcine small intestines ( + channel and depolarize the cell membrane, while also activate the voltage-dependent Ca 2+ channel, causing a Ca 2+ inflow and the generation of action potentials ( 2+ release by activating inositol triphosphate (IP3)

Distant Future: The patents on the active ingredient for popular medications like semaglutide are not expected to expire for several years

Maturitas 2019;126:69-72

These are fair considerations, but they dont outweigh the well-documented benefits from GLP-1s