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Given that Ozempic significantly affects gastrointestinal functionparticularly by slowing gastric emptyingthere are theoretical concerns about how it might interact with the underlying pathophysiology of Crohn's disease

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Patients Who've Failed Lifestyle Intervention: Sustained caloric restriction fails the majority of people who attempt it long-term not because of inadequate motivation, but because the hypothalamic weight-defense mechanisms that evolved to protect against starvation actively counteract weight loss, increasing appetite and reducing metabolic rate in response to caloric deficit