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Conclusion and perspective GLP-1R-independent signaling of GLP-1, its intra-islet axis, and its once-thought inactive metabolites, all represent new important additions to our understanding of this peptide in health and disease

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8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes

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