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Mice were anaesthetised with isoflurane (Isoflurin 1000 mg/ml, Axience, France) and positioned in a stereotaxic frame (Phymep Model 940 Small Animals)

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These numbers suggest that non-response, a significant limitation with earlier GLP-1 medications, becomes much less common with triple-receptor agonism

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This discrepancy between clinical trial data (which rarely prioritises sleep metrics unless explicitly designed to) and real-world experience is common with novel therapeutics

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