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To assess long-term Exe4 secretion by hepatic cells with HITI-mediated knock-in, we transfected Hepa1-6 cells with either HITI donor DNA only (Donor) or the donor plus Cas9 DNAs (Donor+Cas9)

doi: 10.1186/s10194-025-01979-4 Hidayat K, Zhou YY, Du HZ, Qin LQ, Shi BM, Li ZN

However, when semaglutide was studied at higher doses for obesity under the Wegovy brand, a different picture emerged

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