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Randomized trials need to be designed to test that hypothesis directly, not inadvertently suppress it through exclusion criteria
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Closing: The Clinical Bottom Line on What Is MOTS-c MOTS-c is a mitochondrial-derived signaling peptide with a narrow, high-confidence clinical use case: amplifying AMPK-driven metabolic function in patients who have plateaued with diet, training, and standard interventions
If persistent, clinicians sometimes recommend antiemetics such as ondansetron, but this decision requires individualized guidance
