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Of note, the finding of a markedly greater benefit on HF of efpeglenatide amongst trial participants using SGLT2 inhibitors at enrolment in the AMPLITUDE-O CVOT highlights another important point (Lam et al., 2021)

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Schjoedt KJ, Rossing K, Juhl TR et al (2005) Beneficial impact of spironolactone in diabetic nephropathy

Current diabetes treatment guidelines recommend a patient-specific approach to treatment with a goal of achieving glycemic control while minimizing adverse effects, particularly weight gain and hypoglycemia [Inzucchi et al

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