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They require precise chemistry, controlled dosing, prescription oversight, and rigorous clinical validation

doi: 10.1038/ijo.2011.158 [DOI] [PMC free article] [PubMed] [Google Scholar] 89

The molecule was first characterised in published literature by Coskun and colleagues ( Cell Metab , 2022;34(9):1234-1247) as a novel triple agonist with balanced glucagon and GLP-1 receptor activity and relatively greater GIP receptor activity

C., Bakris G

For those already facing semaglutide-induced constipation, a low fiber diet is likely to worsen the condition
