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For example, semaglutide should be stopped at least 2 months before a planned pregnancy according to the manufacturer's guidance

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SURPASS-3 MRI, a sub-study of the phase-3 SURPASS-3 trial assessed tirzepatide administered once per week versus insulin degludec on liver fat content (LFC)

Here are examples of people who cannot be physically active: Those who have injuries that prohibit or limit exercise Those who are getting ready for surgery but need to lose weight (e.g., knee surgery) Those with diabetes or low blood sugar Those with arthritis or other painful conditions Exercise does burn calories immediately, but its not the only option to reduce weight