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Clinical trials reported that approximately 5-7% of participants discontinued treatment due to gastrointestinal side effects

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chin J Hepatol (2005) 13:3747

Our study aimed to investigate the associations between various GLP-1RA types and cancer risk in a large cohort of individuals with obesity

In good news, a recent study found that taking the medication semaglutide had a 20% lower risk of heart attack, stroke, or death due to cardiovascular disease

Important safety considerations include the boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of MTC or MEN2), and risks of pancreatitis, gallbladder problems, diabetic retinopathy complications, and acute kidney injury from dehydration