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Were seeing GLP-1 drugs show tremendous promise across a wide range of conditions, including improving markers of body-wide and brain inflammation, which is common in long COVID, says Eric Topol, executive vice president of Scripps Research and co-principal investigator of LoCITT

Attention will shift toward single-mechanism, assayable ingredients with NDIN filings, identity specs, stability data, and at least one controlled trial

Chronic hyperglycemia, insulin resistance, endothelial dysfunction, and systemic inflammation collectively accelerate atherosclerotic processes

Expanded major adverse cardiovascular events (MACE) were defined as a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, and hospitalization for heart failure

However, a recent randomized controlled trial suggested that liraglutide and sitagliptin did not change the alpha or beta diversity of the gut microbiota, when they were used as add-on therapies with metformin or sulfonylureas (136)