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Contrave highlights of prescribing information, Food and Drug Administration (2024) Wegovy highlights of prescribing information, Food and Drug Administration (2024) Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): A multicentre, randomised, double-blind, placebo-controlled, phase 3 trial, The Lancet (2010) Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension, Diabetes, Obesity and Metabolism (2022) Label: Contrave extended-release naltrexone hydrochloride and bupropion hydrochloride tablet, extended release, DailyMed (2024) Label: Wegovy- semaglutide injection, solution, DailyMed (2024) Update on FDAs ongoing evaluation of reports of suicidal thoughts or actions in patients taking a certain type of medicines approved for Type 2 diabetes and obesity, Food and Drug Administration (2024) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

Strengths and limitations of study This study has several strengths

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Novo Nordisk's semaglutide beats its counterpart liraglutide to become the next generation of weight loss innovation, and then Eli Lilly's GLP-1R/GIPR dual-target agonist tirzepatide achieves a 22.5% weight loss, surpassing semaglutide's weight loss history