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A hypoglycemia episode was defined as a severe hypoglycemia episode or an episode where a laboratory or a self-measured glucose calibrated to plasma was less than 56 mg/dL or where a whole blood glucose was less than 50 mg/dL (i.e., with or without the presence of hypoglycemic symptoms)

This is the core population where semaglutide's risk-benefit profile is well-characterized and the clinical rationale is straightforward

Solomon BL, Wartofsky L, Burman KD
Most weight loss drugs side effects are mild and often go away as the body gets used to the medicine

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