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Second, in humans with loss-of-function variants in SLC22A1, which decrease the uptake of metformin into the liver, the ability of metformin to lower A1c levels is not impaired (48)

Burgmaier M, Liberman A, Mllmann J, Kahles F, Reith S, Lebherz C, et al

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Proper diet, exercise, and nutrition companion products help to preserve the health and quality of muscles

Although, as said above, weight loss induced by GLP-1 RAs comes mainly from reductions in fat mass rather than lean mass, nutritional advice and exercise programmes to achieve muscle strengthening are recommended to minimize sarcopenic risk [74]