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Its effects gradually improve over months as the dose increases and the body adjusts to it

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Clinical data are consistent that weight regain occurs in the majority of patients who discontinue, because the hormonal appetite suppression that drives the weight loss is no longer present

Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including NovoLog Mix 70/30