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GLP-1s are a bottom-up approach, using gut hormones to create a natural feeling of fullness and metabolic balance

doi: 10.1152/AJPHEART.00486.2019 95 WarringtonJPGeorgeEMPaleiACSpradleyFTGrangerJP

It also contradicted a common belief that glucagon helped to promote type 2 diabetes (Tschp, Finan, Clemmensen

(Lausanne) 14 , 1085799 (2023)

HOMA-IR values between 0.5 and 1.4 are considered normal HOMA-IR values 1.9 are indicative of early insulin resistance HOMA-IR values 2.9 indicate insulin resistance I think that a challenge in using GLP1 agonists in this manner is what to do if the drug causes a telogen effluvium