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Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality

doi: 10.3389/fphar.2026.1791206 Received 19 January 2026 Revised 13 April 2026 Accepted 14 April 2026 Published 01 May 2026 Volume 17 - 2026 Edited by Kabirullah Lutfy, Western University of Health Sciences, United States Reviewed by Marsida Kallupi, University of California, San Diego, United States Christina Merritt, University of Texas Medical Branch at Galveston, United States Updates Copyright 2026 Hrickova, Demirci, Amchova and Ruda-Kucerova

Understanding the pharmacological mechanisms, potential interactions, and cardiovascular considerations is essential for safe, effective treatment when these medication classes are prescribed together under specialist supervision

Starting and stopping these medications should always be done with medical supervision