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Because the dosing protocol used in clinical trials may not actually be the most biologically optimal approach

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Experimental studies in animals provide additional insight: GLP-1 analogs increased testosterone synthesis and improved sperm mitochondrial integrity in diabetic and obese models

Crumm, S., Cofan, M., Juskeviciute, E

This gradual increase helps mitigate potential gastrointestinal side effects often associated with GLP-1 receptor agonists