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This is the same additional pathway that tirzepatide uses beyond semaglutide

Reduced body mass often improves blood pressure, potentially causing over-medication

However, some formulations may require refrigeration at 2C to 8C (36F to 46F)

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People on the highest dose of orforglipron lost on average around 10% of their baseline body weight, for instance, compared to the 2.5% average weight loss seen in those taking a placebo